PTSA-catalyzed Mannich-type-cyclization-oxidation tandem reactions: one-pot synthesis of 1,3,5-substituted pyrazoles from aldehydes, hydrazines and alkynes.

نویسندگان

  • Pei Liu
  • Ying-Ming Pan
  • Yan-Li Xu
  • Heng-Shan Wang
چکیده

A convenient one-pot Mannich-type-cyclization-oxidation tandem process has been developed for the synthesis of 1,3,5-trisubstituted pyrazoles derivatives from aldehydes, hydrazines and alkynes using p-toluenesulfonic acid monohydrate (PTSA) as a multifunctional catalyst. This method provides a flexible and rapid route to 1,3,5-trisubstituted pyrazoles.

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عنوان ژورنال:
  • Organic & biomolecular chemistry

دوره 10 24  شماره 

صفحات  -

تاریخ انتشار 2012